The health care provider has prescribed penicillin and probenecid ...

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The health care provider has prescribed penicillin and probenecid for a patient with a sexually transmitted disease. What is the purpose of combining these medications?
 
  a. To accelerate the excretion of the penicillin
  b. To inhibit the absorption of penicillin to allow the drug to remain in the transport phase
  c. To inhibit the excretion of the penicillin
  d. To reduce toxic effects associated with penicillin

Question 2

A patient allergic to penicillin is being evaluated for a gram-negative infection. Which antimicrobial drug class would the health care provider be cautious in prescribing because of a possible cross sensitivity and/or allergic reaction?
 
  a. Cephalosporins
  b. Aminoglycosides
  c. Sulfonamides
  d. Quinolones

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Answer to Question 1

ANS: C
The combination therapy of penicillin and probenecid allows the penicillin to remain in the body longer, which enhances drug availability and action. The combination may be used advantageously in treating serious or resistant infections. Probenecid inhibits the excretion of penicillin, slows down the excretion of penicillin, and does not affect absorption or toxic effects.

Answer to Question 2

ANS: A
Cephalosporins may be used with caution as alternatives when patients are allergic to the penicillins, but cephalosporins are chemically similar in structure to penicillins and may produce a cross sensitivity and/or allergic reaction. Aminoglycosides, sulfonamides, and quinolones do not tend to produce cross sensitivities.

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