Author Question: Dopamine agonists have been linked with which adverse effects in patients with Parkinson's disease? ... (Read 22 times)

sjones · **on:** Jul 24, 2018

Dopamine agonists have been linked with which adverse effects in patients with Parkinson's disease?

a. Oculogyric crisis
b. Tardive dyskinesia
c. Sudden sleep events
d. Akathisia

Question 2

Which vitamin will reduce the therapeutic effects of levodopa?

a. A
b. B6
c. C
d. D

nicoleclaire22 · **Reply #1 on:** Jul 24, 2018

Answer to Question 1

ANS: C
Sleep episodes have been reported with the dopamine agonists bromocriptine, pergolide, pramipexole, and ropinirole. These are described as sleep attacks, including daytime sleep. Oculogyric crisis is an adverse effect of neuroleptic drugs such as phenothiazines.
Tardive dyskinesia is a dystonic adverse effect of neuroleptic drugs such as phenothiazines. Akathisia, associated with neuroleptic drugs used in the treatment of mental disorders, is characterized by motor restlessness accompanied by increased nervous or restless movement. The syndrome may also occur when anti Parkinson drugs are reduced or discontinued.

Answer to Question 2

ANS: B
Pyridoxine (vitamin B6) will reduce the therapeutic effects of levodopa in oral doses of 5 to 10 mg or more. Generally, diets typically have less than 1 mg of vitamin B6 and therefore are not restricted. The ingredients in multivitamins, however, must be assessed. Vitamins A, C, and D do not affect therapy with levodopa.