Which statement(s) about liberation of drugs is/are true? (Select ...

[ahriuashd]

Which statement(s) about liberation of drugs is/are true? (Select all that apply.)
 
  a. A drug must be dissolved in body fluids before it can be absorbed into body tissues.
  b. A solid drug taken orally must disintegrate and dissolve in GI fluids to allow for absorption into the bloodstream for transport to the site of action.
  c. The process of converting the drug into a soluble form can be controlled to a certain degree by the dosage form.
  d. Converting the drug to a soluble form can be influenced by administering the drug with or without food in the patient's stomach.
  e. Elixirs take longer to be liberated from the dosage form.

Question 2

The nurse recognizes that which factor(s) would contribute to digoxin toxicity in a 92-year-old patient? (Select all that apply.)
 
  a. Taking the medication with meals
  b. Prolonged half-life of the drug digoxin
  c. Impaired renal function
  d. Diminished mental capacity

[jojobee318]

Answer to Question 1

ANS: A, B, C, D
Regardless of the route of administration, a drug must be dissolved in body fluids before it can be absorbed into body tissues. Before a solid drug taken orally can be absorbed into the bloodstream for transport to the site of action, it must disintegrate and dissolve in the GI fluids and be transported across the stomach or intestinal lining into the blood. The process of converting a drug into a soluble form can be partially controlled by the pharmaceutical dosage form used (e.g., solution, suspension, capsules, and tablets with various coatings). The conversion process can also be influenced by administering the drug with or without food in the patient's stomach. Elixirs are already drugs dissolved in a liquid and do not need to be liberated from the dosage form.

Answer to Question 2

ANS: B, C
Impaired renal and hepatic function in older adults impairs metabolism and excretion of drugs, thus prolonging the half-life of a medication. Food would decrease the absorption of the drug. Diminished mental capacity does not contribute to drug toxicity unless it is due to administration errors.

[ahriuashd]

Excellent

[aruss1303]

TYSM