Answer to Question 1
Correct Answer: 1
Rationale 1: A biotransformation reaction converts drugs from one form to another that can result in increased or decreased activity.
Rationale 2: Biotransformation is not the final step of excretion of a drug from the body.
Rationale 3: Biotransformation does not change the effect of a drug.
Rationale 4: Biotransformation is not the process of absorption.
Global Rationale: A biotransformation reaction converts drugs from one form to another that can result in increased or decreased activity. Biotransformation is the final step in excretion of a drug from the body; does not change the effect of a drug; is not the process of absorption.
Answer to Question 2
Correct Answer: 1, 2, 4, 5
Rationale 1: Because some drugs are excreted into breast milk, nursing mothers should check with their health care providers before taking any drugs or supplements.
Rationale 2: Urine is the major route of excretion for most drugs.
Rationale 3: Gastric juice is incorrect because it is not a route of excretion for drugs.
Rationale 4: Some drugs are excreted into the bile and are ultimately lost from the body in the feces.
Rationale 5: Some drugs are excreted by the lungs through expiration.
Global Rationale: Drugs can be excreted through breast milk, urine, feces, and the lungs. Gastric juice is incorrect because it is not a route of excretion for drugs.
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