The developmental variation in Phase I enzymes has what impact on pediatric prescribing?
1. None, Phase I enzymes are stable throughout childhood.
2. Children should always be prescribed lower than adult doses per weight due to low enzyme activity until puberty.
3. Children should always be prescribed higher than adult doses per weight due to high enzyme activity.
4. Prescribing dosages will vary based on the developmental activity of each enzyme, at times requiring lower than adult doses and other times higher than adult doses based on the age of the child.
Question 2
Developmental variation in renal function has what impact on prescribing for infants and children?
1. Lower doses of renally excreted drugs may be prescribed to infants younger than age 6 months.
2. Higher doses of water soluble drugs may need to be prescribed because of increased renal excretion.
3. Renal excretion rates have no impact on prescribing.
4. Parents need to be instructed on whether drugs are renally excreted or not.
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