Author Question: Carbamazepine has a Black Box Warning recommending testing for the HLA-B1502 allele in patients with ... (Read 29 times)

c0205847 · **on:** Jul 24, 2018

Carbamazepine has a Black Box Warning recommending testing for the HLA-B1502 allele in patients with Asian ancestry prior to starting therapy due to:

1. Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B1502 allele
2. Increased risk for drug interactions in Asian patients with the HLA-B1502 allele
3. Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B1502 allele
4. Patients who have the HLA-B1502 allele being more likely to have a resistance to carbamazepine

Question 2

Rifampin is a nonspecific CYP450 inducer that may:

1. Lead to toxic levels of rifampin and must be monitored closely
2. Cause toxic levels of drugs, such as oral contraceptives, when coadministered
3. Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
4. Cause nonspecific changes in drug metabolism