Sickle-cell disease is a painful disorder of the red blood cells that in the United States affects mostly blacks. To investigate whether drug A can reduce the pain associated with sickle-cell disease, a study by the National Institutes of Health randomly assigned 150 sickle-cell sufferers to receive the drug. Placebos were given to another 150 sickle-cell sufferers. Great care was used to ensure that the 300 participants did not know if their pill contained the drug. At the end of the treatment period, the researchers counted the number of episodes of pain reported by each subject. Which of the following principles was not used in this study?
a. Control
b. Blinding
c. Randomization
d. Blocking
Question 2
Sickle-cell disease is a painful disorder of the red blood cells that in the United States affects mostly blacks. To investigate whether drug A can reduce the pain associated with sickle-cell disease, a study by the National Institutes of Health randomly assigned 150 sickle-cell sufferers to receive the drug. Placebos were given to another 150 sickle-cell sufferers. Great care was used to ensure that the 300 participants did not know if their pill contained the drug. At the end of the treatment period, the researchers counted the number of episodes of pain reported by each subject. What is the response variable in this study?
a. Sickle-cell disease status (yes or no).
b. Form of drug (pill or liquid).
c. The number of episodes of pain.
d. The number of red blood cells.
The pH of human blood ranges from 7.35 to 7.45.
The United States, 1819
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