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Cancer has been around as long as humankind, but only in the second half of the twentieth century did the number of cancer cases explode.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
Your skin wrinkles if you stay in the bathtub a long time because the outermost layer of skin (which consists of dead keratin) swells when it absorbs water. It is tightly attached to the skin below it, so it compensates for the increased area by wrinkling. This happens to the hands and feet because they have the thickest layer of dead keratin cells.
Though methadone is often used to treat dependency on other opioids, the drug itself can be abused. Crushing or snorting methadone can achieve the opiate "rush" desired by addicts. Improper use such as these can lead to a dangerous dependency on methadone. This drug now accounts for nearly one-third of opioid-related deaths.