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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Illness; diuretics; laxative abuse; hot weather; exercise; sweating; caffeine; alcoholic beverages; starvation diets; inadequate carbohydrate consumption; and diets high in protein, salt, or fiber can cause people to become dehydrated.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.