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An identified risk factor for osteoporosis is the intake of excessive amounts of vitamin A. Dietary intake of approximately double the recommended daily amount of vitamin A, by women, has been shown to reduce bone mineral density and increase the chances for hip fractures compared with women who consumed the recommended daily amount (or less) of vitamin A.
On average, the stomach produces 2 L of hydrochloric acid per day.
Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.


