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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
There are more sensory neurons in the tongue than in any other part of the body.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
An identified risk factor for osteoporosis is the intake of excessive amounts of vitamin A. Dietary intake of approximately double the recommended daily amount of vitamin A, by women, has been shown to reduce bone mineral density and increase the chances for hip fractures compared with women who consumed the recommended daily amount (or less) of vitamin A.