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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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There are approximately 3 million unintended pregnancies in the United States each year.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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More than 4.4billion prescriptions were dispensed within the United States in 2016.
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Medication errors are three times higher among children and infants than with adults.