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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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The horizontal fraction bar was introduced by the Arabs.
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Colchicine is a highly poisonous alkaloid originally extracted from a type of saffron plant that is used mainly to treat gout.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.