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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The Food and Drug Administration has approved Risperdal, an adult antipsychotic drug, for the symptomatic treatment of irritability in children and adolescents with autism. The approval is the first for the use of a drug to treat behaviors associated with autism in children. These behaviors are included under the general heading of irritability and include aggression, deliberate self-injury, and temper tantrums.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
The longest a person has survived after a heart transplant is 24 years.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.