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Chronic marijuana use can damage the white blood cells and reduce the immune system's ability to respond to disease by as much as 40%. Without a strong immune system, the body is vulnerable to all kinds of degenerative and infectious diseases.
Certain rare plants containing cyanide include apricot pits and a type of potato called cassava. Fortunately, only chronic or massive ingestion of any of these plants can lead to serious poisoning.
Multiple experimental evidences have confirmed that at the molecular level, cancer is caused by lesions in cellular DNA.
Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.