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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
Over time, chronic hepatitis B virus and hepatitis C virus infections can progress to advanced liver disease, liver failure, and hepatocellular carcinoma. Unlike other forms, more than 80% of hepatitis C infections become chronic and lead to liver disease. When combined with hepatitis B, hepatitis C now accounts for 75% percent of all cases of liver disease around the world. Liver failure caused by hepatitis C is now leading cause of liver transplants in the United States.
Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.
On average, the stomach produces 2 L of hydrochloric acid per day.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.