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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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It is difficult to obtain enough calcium without consuming milk or other dairy foods.
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There are 20 feet of blood vessels in each square inch of human skin.
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Medication errors are three times higher among children and infants than with adults.