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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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To combat osteoporosis, changes in lifestyle and diet are recommended. At-risk patients should include 1,200 to 1,500 mg of calcium daily either via dietary means or with supplements.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Approximately 25% of all reported medication errors result from some kind of name confusion.