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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Cyanide works by making the human body unable to use oxygen.
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The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.