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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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The training of an anesthesiologist typically requires four years of college, 4 years of medical school, 1 year of internship, and 3 years of residency.