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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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More than 4.4billion prescriptions were dispensed within the United States in 2016.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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All adults should have their cholesterol levels checked once every 5 years. During 2009–2010, 69.4% of Americans age 20 and older reported having their cholesterol checked within the last five years.