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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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Today, nearly 8 out of 10 pregnant women living with HIV (about 1.1 million), receive antiretrovirals.
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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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On average, the stomach produces 2 L of hydrochloric acid per day.