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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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About 3% of all pregnant women will give birth to twins, which is an increase in rate of nearly 60% since the early 1980s.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.