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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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Illicit drug use costs the United States approximately $181 billion every year.