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In 1864, the first barbiturate (barbituric acid) was synthesized.
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.
For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.
Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
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