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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
More than 4.4billion prescriptions were dispensed within the United States in 2016.
Egg cells are about the size of a grain of sand. They are formed inside of a female's ovaries before she is even born.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.