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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.