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People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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It is difficult to obtain enough calcium without consuming milk or other dairy foods.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.