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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Medication errors are more common among seriously ill patients than with those with minor conditions.
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Congestive heart failure is a serious disorder that carries a reduced life expectancy. Heart failure is usually a chronic illness, and it may worsen with infection or other physical stressors.