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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Signs and symptoms of a drug overdose include losing consciousness, fever or sweating, breathing problems, abnormal pulse, and changes in skin color.
More than 34,000 trademarked medication names and more than 10,000 generic medication names are in use in the United States.
The people with the highest levels of LDL are Mexican American males and non-Hispanic black females.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.