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It is difficult to obtain enough calcium without consuming milk or other dairy foods.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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All patients with hyperparathyroidism will develop osteoporosis. The parathyroid glands maintain blood calcium within the normal range. All patients with this disease will continue to lose calcium from their bones every day, and there is no way to prevent the development of osteoporosis as a result.
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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.