Which of the two stereoisomers of 4-t-butylcyclohexyl iodide ...

[cookcarl]

Which of the two stereoisomers of 4-t-butylcyclohexyl iodide (127I) will undergo SN2 substitution with 128I faster, and why?
 
  1.A will react faster because it is more stable
  2.B will react faster because it gives a more stable product.
  3.A will react faster because nucleophiles approach from the bottom face of the molecule is easier for steric reasons.
  4.A and B will react with the same rate because the transition states for both reactions are the same.
  5.B will react faster because it is less stable than A, and the transition state for both reactions is of the same energy.

Question 2

What is the most likely product of the following reaction?
 

Question 3

What is the major product of the following reaction?
 

Question 4

Which of the following is the best nucleophile?
   
  1.H2O
  2.(CH3)3N
  3.(CH3)2P
  4.(CH3)2O
  5.CH3O

[amynguyen1221]

Answer to Question 1

5

Answer to Question 2

1

Answer to Question 3

5

Answer to Question 4

3

[cookcarl]

Great answer, keep it coming

[bdobbins]

Excellent