Author Question: Acetoacetyl-CoA reacts with acetyl-CoA to give product A in the presence of ... (Read 76 times)

TFauchery · **on:** Aug 23, 2018

Acetoacetyl-CoA reacts with acetyl-CoA to give product A in the presence of 3-hydroxy-3-methyl-glutaryl-CoA synthetase. Identify the special feature of this reaction.
a. It is enantioselective, and only the S enantiomer is formed.
b. It is enantioselective, and only the R enantiomer is formed.
c. It produces a non-superposable R enantiomer.
d. It produces a racemic mixture used for various purposes.

Question 2

State two differences between Claisen and Aldol condensations.

chem1s3 · **Reply #1 on:** Aug 23, 2018

Answer to Question 1

a

Answer to Question 2

The two differences between Claisen and Aldol condensations are as follows:
1 . In the case of Claisen condensations, hydroxides cannot be used as a base as they could react with esters, while for Aldol condensations, hydroxides can be used.
2 . In Aldol condensations, no group is lost, but in the case of Claisen condensations, an alkoxide group is lost.