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The use of salicylates dates back 2,500 years to Hippocrates’s recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Thyroid conditions may make getting pregnant impossible.
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The longest a person has survived after a heart transplant is 24 years.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.