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Multiple experimental evidences have confirmed that at the molecular level, cancer is caused by lesions in cellular DNA.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.