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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
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Street names for barbiturates include reds, red devils, yellow jackets, blue heavens, Christmas trees, and rainbows. They are commonly referred to as downers.