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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Individuals are never “cured” of addictions. Instead, they learn how to manage their disease to lead healthy, balanced lives.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.