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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Your heart beats over 36 million times a year.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Fatal fungal infections may be able to resist newer antifungal drugs. Globally, fungal infections are often fatal due to the lack of access to multiple antifungals, which may be required to be utilized in combination. Single antifungals may not be enough to stop a fungal infection from causing the death of a patient.

