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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
There are more bacteria in your mouth than there are people in the world.
On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.