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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
Giardia is one of the most common intestinal parasites worldwide, and infects up to 20% of the world population, mostly in poorer countries with inadequate sanitation. Infections are most common in children, though chronic Giardia is more common in adults.
![The mandrill (Mandrillus sphinx) is a primate of the Old World monkey (Cercopithecidae) family,[3] c](https://biology-forums.com/gallery/47/medium_12359_08_06_12_5_05_05.jpeg)
