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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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More than 4.4billion prescriptions were dispensed within the United States in 2016.
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Approximately 70% of expectant mothers report experiencing some symptoms of morning sickness during the first trimester of pregnancy.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.