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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.
ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.