Answer to Question 1
Answer: Children born in later winter and early spring are more likely to develop schizophrenia, particularly if the family resides in an urban rather than a rural setting. These data suggest that being indoors during the winter exposes the mother (and fetus) to viral illness. Brain toxicity may result when such illness occurs during the second trimester.
Answer to Question 2
Answer: Antipsychotic medications block dopamine receptors. Typical antipsychotic drugs exert strong effects on dopamine receptors in the striatum and reverse positive schizophrenia symptoms. The atypical agent clozapine alters both positive and negative schizophrenia symptoms.