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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).

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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.

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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.

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According to animal studies, the typical American diet is damaging to the liver and may result in allergies, low energy, digestive problems, and a lack of ability to detoxify harmful substances.

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The main avenue to the upward social mobility reviewed in the text has been higher education. The main avenue to the upward social mobility reviewed in the text has been higher education.
Used antifreeze coolant should be kept separate and stored in a leakproof container until it can be ... Used antifreeze coolant should be kept separate and stored in a leakproof container until it can be ...
Heavy fuel droplets separate as they flow around an abrupt bend in an intake manifold. Heavy fuel droplets separate as they flow around an abrupt bend in an intake manifold.
Separate thigh from leg to create six pieces Separate thigh from leg to create six pieces
Video: Glomerular filtrate rate: pressures that affect GFR, NFP & GFR and blood composition

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