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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
Signs and symptoms of a drug overdose include losing consciousness, fever or sweating, breathing problems, abnormal pulse, and changes in skin color.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.

