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The first-known contraceptive was crocodile dung, used in Egypt in 2000 BC. Condoms were also reportedly used, made of animal bladders or intestines.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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In inpatient settings, adverse drug events account for an estimated one in three of all hospital adverse events. They affect approximately 2 million hospital stays every year, and prolong hospital stays by between one and five days.
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Illicit drug use costs the United States approximately $181 billion every year.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.