Answer to Question 1
Answer: The postsynaptic action of many neurotransmitters is terminated via reuptake of the molecule through the membrane transporter. A drug that blocks such a transporter would be expected to raise the synaptic levels of that neurotransmitter. For a disease or disorder that is thought to result from a low synaptic activity of that transmitter, blockade of the reuptake process would generate a beneficial effect.
Answer to Question 2
Answer: To modulate the internal biochemical activity of the presynaptic cell.
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