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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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Hip fractures are the most serious consequences of osteoporosis. The incidence of hip fractures increases with each decade among patients in their 60s to patients in their 90s for both women and men of all populations. Men and women older than 80 years of age show the highest incidence of hip fractures.

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Although the Roman numeral for the number 4 has always been taught to have been "IV," according to historians, the ancient Romans probably used "IIII" most of the time. This is partially backed up by the fact that early grandfather clocks displayed IIII for the number 4 instead of IV. Early clockmakers apparently thought that the IIII balanced out the VIII (used for the number 8) on the clock face and that it just looked better.

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Less than one of every three adults with high LDL cholesterol has the condition under control. Only 48.1% with the condition are being treated for it.

Asthma. (a) A normal bronchiole. (b) An asthmatic bronchiole. During an asthma “attack,” the bronchi Asthma. (a) A normal bronchiole. (b) An asthmatic bronchiole. During an asthma “attack,” the bronchi
Advance Beneficiary Notice Form (ABN). Advance Beneficiary Notice Form (ABN).
Instructions for Completing the CMS-1500 (02/12) Claim Form Continued Instructions for Completing the CMS-1500 (02/12) Claim Form Continued
How to quickly determine the maximum or minimum value of a quadratic equation in standard form How to quickly determine the maximum or minimum value of a quadratic equation in standard form
Bacteria in your GI tract synthesize one form of vitamin K Bacteria in your GI tract synthesize one form of vitamin K
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Video: The Krebs Cycle Animation

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