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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
The tallest man ever known was Robert Wadlow, an American, who reached the height of 8 feet 11 inches. He died at age 26 years from an infection caused by the immense weight of his body (491 pounds) and the stress on his leg bones and muscles.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
By definition, when a medication is administered intravenously, its bioavailability is 100%.
There are approximately 3 million unintended pregnancies in the United States each year.