This topic contains a solution. Click here to go to the answer

Author Question: What is the relative efficacy of antidepressant drug therapy for adults diagnosed with clinical ... (Read 63 times)

BRWH

  • Hero Member
  • *****
  • Posts: 553
What is the relative efficacy of antidepressant drug therapy for adults diagnosed with clinical depression?
 
  What will be an ideal response?

Question 2

Give two pieces of evidence that support the catecholamine hypothesis of depression and one piece of evidence that seems to conflict with the hypothesis.
 
  What will be an ideal response?



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

SVictor

  • Sr. Member
  • ****
  • Posts: 365
Answer to Question 1

Individual medications within the category of FDA-approved antidepressants typically reduce the symptoms in 50-60 of patientscompared with 20-30 response rate with placebo. However, some individuals who do not respond favorably to one type of antidepressant after adequate dosage and length of treatment may respond favorably to another in a different class, e.g., SSRIs, MAOIs, or another drug within the same class, or some combination of antidepressant medications. Tolerability of side effects of the particular antidepressant for the individual may dictate treatment compliance and efficacy.

Answer to Question 2

The actions and behavioral effects of reserpine, MAOIs, amphetamine, and monoamine reuptake blockers are superficially compatible with the hypothesis, because these either deplete or enhance synaptic catecholamine levels, and correspondingly induce or reduce symptoms of depression. However, the lack of correspondence between the onset of drug action and the drugs' clinical efficacy, i.e., the fact that MAOIs and many antidepressants enhance synaptic catecholamine levels rapidly (typically within hours) but exert their benefits in depressed individuals fairly slowly (typically within several days or weeks), is a problem for the hypothesis. Also, clinically effective catecholamine-augmenting antidepressants only elevate mood in depressed individuals. Also, the SSRIs, which have minimal influence on catecholamines, are just as effective as antidepressants as drugs that are potent catecholamine reuptake blockers.




BRWH

  • Member
  • Posts: 553
Reply 2 on: Jun 22, 2018
Excellent


softEldritch

  • Member
  • Posts: 334
Reply 3 on: Yesterday
Gracias!

 

Did you know?

Always store hazardous household chemicals in their original containers out of reach of children. These include bleach, paint, strippers and products containing turpentine, garden chemicals, oven cleaners, fondue fuels, nail polish, and nail polish remover.

Did you know?

Asthma cases in Americans are about 75% higher today than they were in 1980.

Did you know?

The Centers for Disease Control and Prevention has released reports detailing the deaths of infants (younger than 1 year of age) who died after being given cold and cough medications. This underscores the importance of educating parents that children younger than 2 years of age should never be given over-the-counter cold and cough medications without consulting their physicians.

Did you know?

Drug abusers experience the following scenario: The pleasure given by their drug (or drugs) of choice is so strong that it is difficult to eradicate even after years of staying away from the substances involved. Certain triggers may cause a drug abuser to relapse. Research shows that long-term drug abuse results in significant changes in brain function that persist long after an individual stops using drugs. It is most important to realize that the same is true of not just illegal substances but alcohol and tobacco as well.

Did you know?

More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.

For a complete list of videos, visit our video library